The effects of nicotinamide and hyperbaric oxygen on skin flap survival.
Auteur(s)
Collins TM1, Caimi R, Lynch PR, Sheffield J, Mitra A, Stueber K, Smith YR.
Jaartal
1991
Tijdschrift
Scand J Plast Reconstr Surg Hand Surg. 1991;25(1):5-7.
Type publicatie
Onderzoek
Onderzoek
Proefdier
Aantal
40 ratten
Selectiecriteria
-
Methode
Forty Sprague-Dawley male rats (weight 300-350 grams) were treated for 14 days preoperatively 1 day post-operatively with either 400 mg of nicotinamide i.p. or saline i.p. On day 14, a 7 X 7 cm island pedicle skin flap was elevated ligating the left inferior epigastric neurovascular pedicle and were sutured in their normal position. Twenty animals then underwent hyperbaric oxygen treatments. Forty-eight hours post-operatively animals were re-anesthetized and were given a single injection of fluorescein (25 mg/kg) via the tail vein.
Resultaat
The % survival of the flap and SEM of the groups are as follows: Saline 45.67 +/- 31.14, nicotinamide 85.30 +/- 9.24, saline-hyperbaric oxygen 76.70 +/- 9.42 and nicotinamide-hyperbaric oxygen 90.86 +/- 3.94 with statistical significance of p less than 0.01.
Conclusie
Nicotinamide appears to be another acceptable therapeutic modality in the management of the acceleration of wound healing.
Externe link
Indicatie
Myocutane plastieken met circulatieproblemen
