Interventions for replacing missing teeth: hyperbaric oxygen therapy for irradiated patients who require dental implants (Review)
Auteur(s)
Esposito M, Grusovin MG, Patel S, Worthington HV, Coulthard P
Jaartal
2008
Tijdschrift
Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD003603. DOI: 10.1002/14651858.CD003603.pub2.
Type publicatie
Review
Onderzoek
Cochrane systematic review - Literature review
Aantal
1 RCT, 13 patienten, 13 controles
Selectiecriteria
Randomised controlled trials of HBO therapy for irradiated patients requiring dental implants
Methode
We searched the Cochrane Oral Health Group’s Trials Register, The Cochrane Central Register of Controlled Trials (CENTRAL),
MEDLINE and EMBASE. Handsearching included several dental journals. We checked the bibliographies of relevant clinical trials
and review articles for studies outside the handsearched journals. We wrote to authors of the identified randomised controlled trials
(RCTs), to more than 55 oral implant manufacturers; we used personal contacts and we asked on an internet discussion group in an
attempt to identify unpublished or ongoing RCTs. No language restriction was applied. The last electronic search was conducted on
13 June 2007.
MEDLINE and EMBASE. Handsearching included several dental journals. We checked the bibliographies of relevant clinical trials
and review articles for studies outside the handsearched journals. We wrote to authors of the identified randomised controlled trials
(RCTs), to more than 55 oral implant manufacturers; we used personal contacts and we asked on an internet discussion group in an
attempt to identify unpublished or ongoing RCTs. No language restriction was applied. The last electronic search was conducted on
13 June 2007.
Resultaat
Only one RCT was identified and included. Thirteen patients received HBO therapy while other 13 did not. Two to six implants were
placed in fully edentulous mandibles to be rehabilitated with bar-retained overdentures. One year after implant loading four patients
died from each group. One patient, treated with HBO, developed an osteoradionecrosis and lost all implants so the prosthesis could
not be provided. Five patients in the HBO group had at least one implant failure versus two in the control group. There were no
statistically significant differences for prosthesis and implant failures, postoperative complications and patient satisfaction between the
two groups.
placed in fully edentulous mandibles to be rehabilitated with bar-retained overdentures. One year after implant loading four patients
died from each group. One patient, treated with HBO, developed an osteoradionecrosis and lost all implants so the prosthesis could
not be provided. Five patients in the HBO group had at least one implant failure versus two in the control group. There were no
statistically significant differences for prosthesis and implant failures, postoperative complications and patient satisfaction between the
two groups.
Conclusie
Despite the limited amount of clinical research available, it appears that HBO therapy in irradiated patients requiring dental implants
may not offer any appreciable clinical benefits. There is a definite need for more RCTs to ascertain the effectiveness of HBO in irradiated
patients requiring dental implants. These trials ought to be of a high quality and reported as recommended by the CONSORT statement
(www.consort-statement.org/). Each clinical centre may have limited numbers of patients and it is likely that trials will need to be
multicentred.
may not offer any appreciable clinical benefits. There is a definite need for more RCTs to ascertain the effectiveness of HBO in irradiated
patients requiring dental implants. These trials ought to be of a high quality and reported as recommended by the CONSORT statement
(www.consort-statement.org/). Each clinical centre may have limited numbers of patients and it is likely that trials will need to be
multicentred.
Externe link
Indicatie
