Hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis
Auteur(s)
Takahiro Yoshida, Atsunari Kawashima,Takeshi Ujike,Motohide Uemura,Kensaku Nishimura and Susumu Miyoshi
Jaartal
2008
Tijdschrift
International Journal of Urology (2008) 15, 639–641
Type publicatie
Onderzoek
Onderzoek
Cohort analyse
Aantal
8
Selectiecriteria
Hemorrhagische radiatiecystitis
Methode
100% oxygen in a walk-in multiplace hyperbaric chamber at a pressure of 2.0 atmospheres absolute for 90 min, 5 days a week. Evaluation after each 10th session
Resultaat
A mean of 19 (range 10–42) HBO treatments was performed. Of the eight patients, six had complete resolution of hematuria during or after HBO therapy. One of the six experienced recurrence of hematuria and
received additional treatments for each relapse. This patient received a total of 42 HBO treatments before hematuria finally resolved. Of the eight patients two exhibited no improvement of hematuria at all. One
patient who had received radiation as adjuvant therapy after prostatectomy suffered from vesicointestinal fistula 20 months after HBO therapy. He underwent urinary and intestinal diversion but eventually
died from a pelvic abscess without relapse of the primary malignancy. The other patient is alive but suffering from severe hemorrhagic cystitis at the time of this submission, and cystectomy and urinary diversion are
being considered for treatment. No major adverse effects were observed in the patients undergoing HBO therapy.
received additional treatments for each relapse. This patient received a total of 42 HBO treatments before hematuria finally resolved. Of the eight patients two exhibited no improvement of hematuria at all. One
patient who had received radiation as adjuvant therapy after prostatectomy suffered from vesicointestinal fistula 20 months after HBO therapy. He underwent urinary and intestinal diversion but eventually
died from a pelvic abscess without relapse of the primary malignancy. The other patient is alive but suffering from severe hemorrhagic cystitis at the time of this submission, and cystectomy and urinary diversion are
being considered for treatment. No major adverse effects were observed in the patients undergoing HBO therapy.
Conclusie
HBO therapy has recently emerged as a potential primary option for the management of hemorrhagic cystitis because of its high positive response rate. In addition, since its potential side-effects are usually well tolerated, HBO therapy should be attempted for radiation-induced hemorrhagic cystitis.
Externe link
Indicatie
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